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Emerin, Mouse anti-Human, Clone: EMD/2167, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP279784100UG

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Catalog No. NB010585


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Description

Description

Emerin Monoclonal antibody specifically detects Emerin in Human Samples. It is validated for Western Blot, Immunohistochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Protein Array.
Specifications

Specifications

Emerin
EMD/2167
Unconjugated
10 mM PBS with 0.05% BSA
Purified
EMD
Recombinant human Emerin protein fragment (around aa 56-167) (exact sequence is proprietary)
Protein A or G purified
RUO
Primary
2010
Human
Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Peptide Array, Western Blot
0.2 mg/mL
Western Blot 1-2 ug/ml, Immunohistochemistry 1-2 ug/ml, Immunocytochemistry/Immunofluorescence 1-3 ug/ml, Immunohistochemistry-Paraffin 1-2 ug/ml, Protein Array
P50402
emerin, Emery-Dreifuss muscular dystrophy, LEM domain containing 5, STAEDMDLEMD5
Mouse
IgG1 Kappa
100 ug
Store at 4°C.
Monoclonal
Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma.
SDS
Documents
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