Emerin, Mouse anti-Human, Clone: EMD/2167, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP27978420UG

Catalog No. NB010586

Description

Emerin Monoclonal specifically detects Emerin in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Protein Array.

Specifications

• Antigen: Emerin
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Dilution: Western Blot 1-2 ug/ml, Immunohistochemistry 1-2 ug/ml, Immunocytochemistry/Immunofluorescence 1-3 ug/ml, Immunohistochemistry-Paraffin 1-2 ug/ml, Protein Array
• Gene Accession No.: P50402
• Gene Symbols: EMD
• Immunogen: Recombinant human Emerin protein fragment (around aa 56-167) (exact sequence is proprietary)
• Quantity: 20 μg
• Primary or Secondary: Primary
• Test Specificity: Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma.
• Content And Storage: Store at 4°C.
• Isotype: IgG1 κ

• Applications: Western Blot, Immunohistochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Peptide Array
• Clone: EMD/2167
• Conjugate: Unconjugated
• Formulation: 10 mM PBS with 0.05% BSA
• Gene Alias: emerin, Emery-Dreifuss muscular dystrophy, LEM domain containing 5, STAEDMDLEMD5
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Gene ID (Entrez): 2010
• Target Species: Human
• Form: Purified