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EMI1 Antibody (EMI1/1176), Novus Biologicals™
SDP

Catalog No. NBP24434400 Shop All R&D Systems Products
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NBP24434400 0.02 mg
NBP24434401 0.1 mg
NBP24434402 0.2 mg
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Catalog No. NBP24434400 Supplier Novus Biologicals Supplier No. NBP2443440.02MG
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Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

EMI1 Monoclonal specifically detects EMI1 in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.

Specifications

Antigen EMI1
Applications Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone EMI1/1176
Concentration 0.2mg/mL
Conjugate Unconjugated
Dilution Western Blot 1 - 2 ug/ml, Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Accession No. Q9UKT4
Gene Alias EMI1Early mitotic inhibitor 1, F-box only protein 5, F-box protein 5, FBX5F-box protein Fbx5, Fbxo31
Gene Symbols FBXO5
Host Species Mouse
Immunogen Recombinant fragment (203 amino acid residues between aa 1-250) of human EMI1 protein
Molecular Weight of Antigen 56 kDa
Purification Method Protein A or G purified
Quantity 0.02 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26271
Test Specificity It recognizes a 56kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG2a κ
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