Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (A7L6), Novus Biologicals™

Rat Monoclonal Antibody

Supplier:  Novus Biologicals NBP2444480.1MG

Catalog No. NBP24444801

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Monoclonal specifically detects Endorepellin/Perlecan/Heparan Sulfate Proteoglycan in Human, Mouse, Porcine, Bovine, Fish, Monkey samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunofluorescence.

Specifications

• Antigen: Endorepellin/Perlecan/Heparan Sulfate Proteoglycan
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 1 - 2 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
• Gene Accession No.: P98160
• Gene Symbols: HSPG2
• Immunogen: Murine EHS laminin preparation
• Quantity: 0.1 mg
• Primary or Secondary: Primary
• Test Specificity: This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
• Content And Storage: Store at 4C.
• Isotype: IgG2a κ

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
• Clone: A7L6
• Conjugate: Unconjugated
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Alias: basement membrane-specific heparan sulfate proteoglycan core protein, endorepellin (domain V region), heparan sulfate proteoglycan 2, HSPG, perlecan, perlecan proteoglycan, PLCSchwartz-Jampel syndrome 1 (chondrodystrophic myotonia), PRCAN, SJA, SJS, SJS1
• Host Species: Rat
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Gene ID (Entrez): 3339
• Target Species: Human, Mouse, Pig, Fish, Monkey
• Form: Purified

For Research Use Only