Invitrogen™ EpoR Recombinant Rabbit Monoclonal Antibody (4O8U2)

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
MA557949	Invitrogen™ MA557949	20 μL
MA557950	Invitrogen™ MA557950	100 μL

Description

Immunogen sequence: APPPNLPDPK FESKAALLAA RGPEELLCFT ERLEDLVCFW EEAASAGVGP GNYSFSYQLE DEPWKLCRLH QAPTARGAVR FWCSLPTADT SSFVPLELRV TAASGAPRYH RVIHINEVVL LDAPVGLVAR LADESGHVVL RWLPPPETPM TSHIRYEVDV SAGNGAGSVQ RVEILEGRTE CVLSNLRGRT RYTFAVRARM AEPSFGGFWS AWSEPVSLLT PSDLD.

EpoR encodes the erythropoietin receptor, which belongs to the cytokine receptor family. When erythropoietin binds to this receptor, it activates the Jak2 tyrosine kinase, which in turn activates various intracellular pathways including Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors. The stimulated erythropoietin receptor plays a role in the survival of erythroid cells. Defects in this gene may result in erythroleukemia and familial erythrocytosis. Dysregulation of this gene may also affect the growth of certain tumors. Multiple transcript variants are produced as a result of alternate splicing. Diseases associated with EPOR include Erythrocytosis, Familial, 1 and Erythroleukemia.

Specifications

• Antigen: EpoR
• Concentration: 1 mg/mL
• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P19235
• Gene ID (Entrez): 2057
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-249 of human EPOR (NP_000112.1).
• Product Type: Antibody

• Clone: 4O8U2
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: EPOR
• Gene Alias: EPO R; EPOR; EPO-R; Erythropoietin receptor; pEpoR
• Gene Symbols: EPOR
• Primary or Secondary: Primary
• Purification Method: Protein A