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EPS15L Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501559560
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50-155-9560 20 μL
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Catalog No. 50-155-9560 Supplier Bethyl Laboratories, Inc Supplier No. A301731AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. The process of target selection, covalent attachment and shuttle to the 26S proteasome is a vital means of regulating the concentrations of key regulatory proteins in the cell by limiting their lifespans. Polyubiquitination is a common feature of this modification. Serial steps for modification include the activation of ubiquitin, an ATP-dependent formation of a thioester bond between ubiquitin and the enzyme E1, transfer by transacylation of ubiquitin from E1 to the ubiquitin conjugating enzyme E2, and covalent linkage to the target protein directly by E2 or via E3 ligase enzyme. Deubiquitination enzymes also exist to reverse the marking of protein substrates. Posttranslational tagging by Ub is involved in a multitude of cellular processes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, stress responses, the immune response, and nervous system functions.

Specifications

Antigen EPS15L
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene EPS15L1
Gene Accession No. Q9UBC2
Gene Alias Epidermal growth factor receptor substrate 15-like 1; Eps15-related protein; EPS15L1
Gene Symbols EPS15L1
Host Species Rabbit
Immunogen Between 814 and 864
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 58513
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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