Invitrogen™ Epstein Barr Virus LMP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5117557

Catalog No. PIPA5117557

Description

This antibody has been tested in direct-ELISA.

Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.

Specifications

• Antigen: Epstein Barr Virus LMP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Immunogen: Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147aa).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov