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ER beta/NR3A2 Antibody (ERb455), Alexa Fluor™ 700, Novus Biologicals™
SDP

Catalog No. NBP233066Z Shop All R&D Systems Products
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NBP233066Z 0.1 mL
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Catalog No. NBP233066Z Supplier Novus Biologicals Supplier No. NBP233066AF700
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Description

Mouse Monoclonal Antibody

ER beta/NR3A2 Monoclonal specifically detects ER beta/NR3A2 in Human, Mouse, Rat, Porcine, Equine, Monkey, Sheep samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen ER beta/NR3A2
Applications Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Classification Monoclonal
Clone ERb455
Conjugate Alexa Fluor 700
Dilution Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Gene Alias Erb, ER-beta, ESR-BETA, ESTRB, estrogen receptor 2 (ER beta), estrogen receptor beta, estrogen receptor beta 4, NR3A2ESRB, Nuclear receptor subfamily 3 group A member 2
Gene Symbols ESR2
Host Species Mouse
Immunogen C-terminus fragment of recombinant human ER beta/NR3A2 protein (Uniprot: Q92731)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Breast Cancer, Cancer, Cell Biology, Cell Cycle and Replication, Dendritic Cell Markers, GPCR, Neuroscience, Signal Transduction, Transcription Factors and Regulators
Primary or Secondary Primary
Gene ID (Entrez) 2100
Test Specificity Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
Target Species Human, Mouse, Rat, Pig, Equine, Primate, Sheep
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG2a κ
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For Research Use Only

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