ER beta/NR3A2 Antibody (ERb455), Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP229439	Novus Biologicals NBP229439	0.1 mg

Description

ER beta/NR3A2 Monoclonal specifically detects ER beta/NR3A2 in Human, Mouse, Rat, Porcine, Equine, Monkey, Sheep samples. It is validated for Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

• Antigen: ER beta/NR3A2
• Concentration: 0.2 mg/ml
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human, Mouse, Rat, Pig, Equine, Primate, Sheep
• Gene Alias: Erb, ER-beta, ESR-BETA, ESTRB, estrogen receptor 2 (ER beta), estrogen receptor beta, estrogen receptor beta 4, NR3A2ESRB, Nuclear receptor subfamily 3 group A member 2
• Gene Symbols: ESR2
• Isotype: IgG2a κ
• Purification Method: Protein A or G purified
• Test Specificity: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

• Clone: ERb455
• Applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Breast Cancer, Cancer, Cell Biology, Cell Cycle and Replication, Dendritic Cell Markers, GPCR, Neuroscience, Signal Transduction, Transcription Factors and Regulators
• Gene Accession No.: Q92731
• Gene ID (Entrez): 2100
• Immunogen: C-terminus fragment of recombinant human ER beta/NR3A2 protein (Uniprot: Q92731)
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.

For Research Use Only