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ERBB4 Monoclonal Antibody (OTI1H6), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA804606

Encompass_Preferred

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Catalog No. 50-168-0322


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Description

Description

ErbB 4 (Her-4, c-erbB-4, v-erbB-4) is a member of the class I receptor kinase family. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. ErbB 4 is activated by neuregulins and NTAK (neural and thymus derived activator for ErbB kinases). ErbB 4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. ErbB 4 is most predomitly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDAMB-330 and MDA-MB-361. Expression of ErbB 4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3. ErbB 4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some maligcies.
Specifications

Specifications

ERBB4
Monoclonal
Unconjugated
ERBB4
ALS19, HER4, p180erbB4
Mouse
Affinity Chromatography
RUO
2066
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Immunohistochemistry (Paraffin)
OTI1H6
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q15303
ERBB4
Human recombit protein fragment corresponding to amino acids 992-1308 of human ERBB4 produced in E.coli.
100 μL
Primary
Human
Antibody
IgG2b
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