ETS1 associated protein II Antibody (TDP2/1258), DyLight 650, Novus Biologicals™

Catalog No.	Quantity
NB007644	0.1 mL

Catalog No. NB007644 Supplier Novus Biologicals Supplier No. NBP250071C

Description

Mouse Monoclonal Antibody

ETS1 associated protein II Monoclonal specifically detects ETS1 associated protein II in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

• Antigen: ETS1 associated protein II
• Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
• Classification: Monoclonal
• Clone: TDP2/1258
• Conjugate: DyLight 650
• Dilution: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Alias: AD022, dJ30M3.3, EAP2, EAPII, EC 3.1.4.-, ETS1-associated protein 2, ETS1-associated protein II, MGC111021,5'-Tyr-DNA phosphodiesterase, MGC9099,5'-tyrosyl-DNA phosphodiesterase, TRAF and TNF receptor associated protein, TTRAPTRAF and TNF receptor-associated protein, Tyr-DNA phosphodiesterase 2, tyrosyl-DNA phosphodiesterase 2
• Gene Symbols: TDP2
• Host Species: Mouse
• Immunogen: Recombinant full-length human ETS1 associated protein II protein (Uniprot: O95551)
• Purification Method: Protein A or G purified
• Quantity: 0.1 mL
• Regulatory Status: RUO
• Research Discipline: Signal Transduction, Transcription Factors and Regulators
• Primary or Secondary: Primary
• Test Specificity: This MAb recognizes a protein of 41kDa, which is identified as TDP2. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
• Target Species: Human
• Content And Storage: Store at 4°C in the dark.
• Isotype: IgG2b κ