F10 Monoclonal Antibody (OTI3A9), TrueMAB™, OriGene 

Catalog No.	Quantity
50-168-4208	100 μL

Catalog No. 50-168-4208 Supplier OriGene Supplier No. TA811724

Description

Mouse Monoclonal Antibody

F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

Specifications

• Antigen: F10
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI3A9
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: F10
• Gene Accession No.: P00742
• Gene Alias: FX, FXA
• Gene Symbols: F10
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 41-488 of human F10 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2159
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1