F10 Monoclonal Antibody (OTI3A9), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA811724

Catalog No. 50-168-4208

Description

F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

Specifications

• Antigen: F10
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P00742
• Gene Symbols: F10
• Immunogen: Human recombit protein fragment corresponding to amino acids 41-488 of human F10 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI3A9
• Conjugate: Unconjugated
• Gene: F10
• Gene Alias: FX, FXA
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2159
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid