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  6. Fas/TNFRSF6/CD95 Antibody (B-R18) - Azide and BSA Free, Novus Biologicals™

Fas/TNFRSF6/CD95 Antibody (B-R18) - Azide and BSA Free, Novus Biologicals™
SDP

Catalog No. NBP247918B Shop All R&D Systems Products
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0.2 mg
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NBP247918B 0.2 mg
NBP247918A 0.1 mg
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Catalog No. NBP247918B Supplier Novus Biologicals Supplier No. NBP2479180.2MG

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Mouse Monoclonal Antibody

Fas/TNFRSF6/CD95 Monoclonal antibody specifically detects Antigen in Human samples. It is validated for Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen).

Specifications

Antigen Fas/TNFRSF6/CD95
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunofluorescence, CyTOF
Classification Monoclonal
Clone B-R18
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Frozen : 0.5 - 1.0 ug/ml, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready
Formulation PBS with No Preservative
Gene Alias Apo-1 antigen, apoptosis antigen 1, Apoptosis-mediating surface antigen FAS, APT1FASTM, CD95 antigen, CD95ALPS1A, Fas (TNF receptor superfamily, member 6), Fas AMA, Fas antigen, FAS1, FASLG receptor, TNFRSF6member 6, tumor necrosis factor receptor superfamily member 6
Gene Symbols FAS
Host Species Mouse
Immunogen Recombinant human CD95 protein
Purification Method Protein A or G purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer, Cell Biology, Death Receptor Signaling Pathway, Diabetes Research, Inhibitors Activators and Regulators
Primary or Secondary Primary
Gene ID (Entrez) 355
Test Specificity MAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.
Target Species Human
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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