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Fas/TNFRSF6/CD95 Antibody (B-R18), Novus Biologicals™
SDP

Catalog No. NBP24458102 Shop All R&D Systems Products
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NBP24458102 0.2 mg
NBP24458100 0.02 mg
NBP24458101 0.1 mg
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Catalog No. NBP24458102 Supplier Novus Biologicals Supplier No. NBP2445810.2MG

Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Frozen), Immunofluorescence

Fas/TNFRSF6/CD95 Monoclonal antibody specifically detects Fas/TNFRSF6/CD95 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry-Frozen, SDS-Page, Immunofluorescence.

Specifications

Antigen Fas/TNFRSF6/CD95
Applications Flow Cytometry, Immunohistochemistry (Frozen), SDS-Page, Immunofluorescence
Classification Monoclonal
Clone B-R18
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Frozen 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Accession No. P25445
Gene Alias Apo-1 antigen, apoptosis antigen 1, Apoptosis-mediating surface antigen FAS, APT1FASTM, CD95 antigen, CD95ALPS1A, Fas (TNF receptor superfamily, member 6), Fas AMA, Fas antigen, FAS1, FASLG receptor, TNFRSF6member 6, tumor necrosis factor receptor superfamily member 6
Gene Symbols FAS
Host Species Mouse
Immunogen Recombinant human CD95 protein
Purification Method Protein A or G purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer, Cell Biology, Death Receptor Signaling Pathway, Diabetes Research, Inhibitors Activators and Regulators
Primary or Secondary Primary
Gene ID (Entrez) 355
Test Specificity MAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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