Fascin Antibody (FSCN1/418), Allophycocyanin/Cy7, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP247802APCCY7

Catalog No. N247802APC7

Description

Fascin Monoclonal specifically detects Fascin in Human, Rat samples. It is validated for Flow Cytometry.

Specifications

• Antigen: Fascin
• Classification: Monoclonal
• Conjugate: APC-Cyanine7
• Formulation: PBS with 0.05% Sodium Azide
• Gene Symbols: FSCN1
• Immunogen: Full length recombinant human Fascin protein (Uniprot: Q16658)
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkins disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
• Content And Storage: Store at 4°C in the dark. Do not freeze.

• Applications: Flow Cytometry
• Clone: FSCN1/418
• Dilution: Flow Cytometry
• Gene Alias: FAN1,55 kDa actin-bundling protein, fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), FLJ38511, HSN, p55actin bundling protein, singed (Drosophila)-like (sea urchin fascin homolog like), singed-like (fascin homolog, sea urchin), Singed-like protein, SNLfascin
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Research Discipline: Cytoskeleton Markers
• Gene ID (Entrez): 6624.0
• Target Species: Human, Rat
• Isotype: IgG2b κ