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Fascin Antibody (FSCN1/418), Allophycocyanin/Cy7, Novus Biologicals™
SDP

Catalog No. N247802APC7 Shop All R&D Systems Products
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N247802APC7 0.1 mL
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Catalog No. N247802APC7 Supplier Novus Biologicals Supplier No. NBP247802APCCY7
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Description

Mouse Monoclonal Antibody

Fascin Monoclonal specifically detects Fascin in Human, Rat samples. It is validated for Flow Cytometry.

Specifications

Antigen Fascin
Applications Flow Cytometry
Classification Monoclonal
Clone FSCN1/418
Conjugate APC-Cyanine7
Dilution Flow Cytometry
Formulation PBS with 0.05% Sodium Azide
Gene Alias FAN1,55 kDa actin-bundling protein, fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), FLJ38511, HSN, p55actin bundling protein, singed (Drosophila)-like (sea urchin fascin homolog like), singed-like (fascin homolog, sea urchin), Singed-like protein, SNLfascin
Gene Symbols FSCN1
Host Species Mouse
Immunogen Full length recombinant human Fascin protein (Uniprot: Q16658)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cytoskeleton Markers
Primary or Secondary Primary
Gene ID (Entrez) 6624.0
Test Specificity Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkins disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Target Species Human, Rat
Content And Storage Store at 4°C in the dark. Do not freeze.
Isotype IgG2b κ
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