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Fc gamma RIIA/CD32a Antibody (8.7), Novus Biologicals™
SDP

Catalog No. NBP24472202 Shop All R&D Systems Products
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NBP24472202 0.2 mg
NBP24472200 0.02 mg
NBP24472201 0.1 mg
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Catalog No. NBP24472202 Supplier Novus Biologicals Supplier No. NBP2447220.2MG

Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

Fc gamma RIIA/CD32a Monoclonal antibody specifically detects Fc gamma RIIA/CD32a in Human samples. It is validated for Flow Cytometry, SDS-Page, Immunofluorescence.

Specifications

Antigen Fc gamma RIIA/CD32a
Applications Flow Cytometry, SDS-Page, Immunofluorescence
Classification Monoclonal
Clone 8.7
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Accession No. P12318
Gene Alias CD32 antigen, CD32A, CD32MGC23887, CDw32fc-gamma-RIIa, Fc fragment of IgG, low affinity IIa, receptor (CD32), Fc fragment of IgG, low affinity IIa, receptor for (CD32), FCG2, Fc-gamma RII-a, Fc-gamma-RIIa, FcGR, FCGR2, FCGR2A1, FcRII-a, IGFR2MGC30032, IgG Fc receptor II-a, Immunoglobulin G Fc receptor II, low affinity immunoglobulin gamma Fc region receptor II-a
Gene Symbols FCGR2A
Host Species Mouse
Immunogen K562 and FcgRII+L cells
Molecular Weight of Antigen 40 kDa
Purification Method Protein A or G purified
Quantity 0.2 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2212
Test Specificity This MAb reacts with a CD32 (FcgRII) epitope distinct from that defined by MAb 8.26 and the epitope overlaps with that of MAb 7.30 (cluster 4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (Fc?RII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune compl
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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