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Fc gamma RIII (CD16) Antibody (ICO-116), Allophycocyanin/Cy7, Novus Biologicals™
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Catalog No. N24795APCY7 Shop All R&D Systems Products
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N24795APCY7 0.1 mL
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Catalog No. N24795APCY7 Supplier Novus Biologicals Supplier No. NBP247955APCCY7
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Description

Mouse Monoclonal Antibody

Fc gamma RIII (CD16) Monoclonal specifically detects Fc gamma RIII (CD16) in Human samples. It is validated for Flow Cytometry.

Specifications

Antigen Fc gamma RIIIA/CD16a
Applications Flow Cytometry
Classification Monoclonal
Clone ICO-116
Conjugate APC-Cyanine7
Dilution Flow Cytometry
Formulation PBS with 0.05% Sodium Azide
Gene Alias CD16a, CD16a antigen, CD16FCRIIIA, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc fragment of IgG, low affinity IIIa, receptor for (CD16), Fc gamma receptor III-A, FCG3, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIIIa, Fc-gamma RIII-alpha, FCGR3, FCGRIII, FCR-10, FcRIII, FcRIIIa, IGFR3FcgammaRIIIA, immunoglobulin G Fc receptor III, low affinity III, receptor for (CD16), low affinity immunoglobulin gamma Fc region receptor III-A, neutrophil-specific antigen NA
Gene Symbols FCGR3A
Host Species Mouse
Immunogen Human Fc gamma RIII (CD16) protein (Uniprot: P08637)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cell Biology, Cellular Markers, Cytokine Research, Growth and Development, Hematopoietic Stem Cell Markers, Immunology, Innate Immunity, Neuronal Cell Markers, Neuroscience, Stem Cell Markers, Stem Cells
Primary or Secondary Primary
Gene ID (Entrez) 2214.0
Test Specificity It recognizes CD16 (Fcgamma RIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16, CD16A (Fcgamma RIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fcgamma RIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
Target Species Human
Content And Storage Store at 4°C in the dark. Do not freeze.
Isotype IgG1 κ
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