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Fc gamma RIIIA/CD16a Antibody (3G8), Alexa Fluor™ 405, Novus Biologicals™
SDP

Catalog No. NB016113 Shop All R&D Systems Products
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NB016113 0.1 mL
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Catalog No. NB016113 Supplier Novus Biologicals Supplier No. NBP281102AF405

Description

Rabbit Monoclonal Antibody

Fc gamma RIIIA/CD16a Monoclonal specifically detects Fc gamma RIIIA/CD16a in Human, Baboon, Chimpanzee, Cynomolgus Monkey, Rhesus Macaque samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence.

Specifications

Antigen Fc gamma RIIIA/CD16a
Applications Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence
Classification Monoclonal
Clone 3G8
Conjugate Alexa Fluor 405
Dilution Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence
Formulation 50mM Sodium Borate
Gene Alias CD16a, CD16a antigen, CD16FCRIIIA, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc fragment of IgG, low affinity IIIa, receptor for (CD16), Fc gamma receptor III-A, FCG3, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIIIa, Fc-gamma RIII-alpha, FCGR3, FCGRIII, FCR-10, FcRIII, FcRIIIa, IGFR3FcgammaRIIIA, immunoglobulin G Fc receptor III, low affinity III, receptor for (CD16), low affinity immunoglobulin gamma Fc region receptor III-A, neutrophil-specific antigen NA
Gene Symbols FCGR3A
Host Species Rabbit
Immunogen 3G8 was prepared by immunizing mice with human PMN (polymorphonuclear leukocytes) cells.
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Cell Biology, Cellular Markers, Cytokine Research, Growth and Development, Hematopoietic Stem Cell Markers, Immunology, Innate Immunity, Neuronal Cell Markers, Neuroscience, Stem Cell Markers, Stem Cells
Primary or Secondary Primary
Gene ID (Entrez) 2214
Test Specificity 3G8 binds to CD16 at an epitope which is not the IgG-binding site. This antibody cannot distinguish between CD16a transmembrane isoform found on the surface of NK cells and macrophages (which can trigger the cytolytic response), and the GPI-linked CD16b isoform present on neutrophils or soluble CD16 found in the plasma. CD16 is the low affinity IgG receptor III and binds to aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis and ADCC (antibody-dependent cell-mediated cytotoxicity).
Target Species Human, Baboon, Chimpanzee, Cynomolgus Monkey, Rhesus Macaque
Content And Storage Store at 4°C in the dark.
Form Purified
Isotype IgG κ
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