Fibronectin/Anastellin Mouse, Clone: TV-1, Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP232849F	Novus Biologicals NBP2328490.02MG	0.02 mg
NBP232849A	Novus Biologicals NBP2328490.1MG	0.1 mg
NBP232849B	Novus Biologicals NBP2328490.2MG	0.2 mg

Description

Fibronectin Monoclonal specifically detects Fibronectin in Human, Mouse, Rat, Porcine samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Fibronectin
• Dilution: Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, Immunohistochemistry-Frozen 0.5-1.0ug/ml
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human, Mouse, Rat, Porcine
• Gene Accession No.: P02751
• Gene ID (Entrez): 2335
• Immunogen: T-cell lymphoma biopsy
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.

• Clone: TV-1
• Applications: Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Cancer, Cellular Markers, Extracellular Matrix, Mesenchymal Stem Cell Markers, Neuronal Stem Cell Markers, Stem Cell Markers
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Alias: CIGDKFZp686O13149, Cold-insoluble globulin, DKFZp686F10164, DKFZp686H0342, DKFZp686I1370, fibronectin, fibronectin 1, FNFINC, FNZ, GFND2ED-B, LETSGFND, migration-stimulating factor, MSF
• Gene Symbols: FN1
• Isotype: IgG1 κ
• Purification Method: Protein A purified
• Test Specificity: Fibronectin is a soluble dimeric glycoprotein of 440kDa, which is present in cells, extracellular matrix, and blood. This MAb reacts with the cellular as well as plasma form of fibronectin. Reportedly, after iv administration, this MAb localizes to tumor vessels where it binds to the underlying basement. Epitope recognized by this antibody is not accessible in normal tissues to the circulating MAb indicating that it can be used to specifically target tumor vessels in vivo. TV-1 is reportedly useful for delivering vasoactive agents to tumors to induce increased vascular permeability or blood flow prior to treatment with chemotherapeutic drugs or MAbs.