FIS1 Rabbit anti-Human, Mouse, Porcine, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 109561AP150UL

Catalog No. 50-172-6742

Description

This antibody was raised against the full-length of human Fis1 protein, and recognizes endogenous Fis1 protein in various lysates.

Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.

Specifications

• Antigen: FIS1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FIS1
• Gene Alias: CGI 135, FIS1, FIS1 homolog, hFis1, TPR repeat protein 11, TTC11
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100622909, 288584, 51024, 66437
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 0.33 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: P84817, Q9CQ92, Q9Y3D6
• Gene Symbols: Fis1
• Immunogen: FIS1 Fusion Protein Ag1409
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Pig, Rat
• Product Type: Antibody
• Isotype: IgG