FIS1 Rabbit anti-Human, Mouse, Porcine, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-6742	Proteintech Group Inc 109561AP150UL	150 μL

Description

This antibody was raised against the full-length of human Fis1 protein, and recognizes endogenous Fis1 protein in various lysates.

Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.

Specifications

• Antigen: FIS1
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Pig, Rat
• Gene Accession No.: P84817, Q9CQ92, Q9Y3D6
• Gene ID (Entrez): 100622909, 288584, 51024, 66437
• Immunogen: FIS1 Fusion Protein Ag1409
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: FIS1

• Concentration: 0.33 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: CGI 135, FIS1, FIS1 homolog, hFis1, TPR repeat protein 11, TTC11
• Gene Symbols: Fis1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody