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FKBP-135 Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7140042
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50-155-7112 20 μL
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Catalog No. 50-155-7112 Supplier Bethyl Laboratories, Inc Supplier No. A300209AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.

Specifications

Antigen FKBP-135
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene FKBP15
Gene Accession No. Q5T1M5, Q6P9Q6
Gene Alias FKBP133, KIAA0674, PPP1R76; 133 kDa FK506-binding protein; 133 kDa FKBP; FK506-binding protein 133kDa; FK506-binding protein 15; FKBP-133; FKBP-15; WAFL; protein phosphatase 1, regulatory subunit 76
Gene Symbols FKBP15
Host Species Rabbit
Immunogen Between 50 and 100
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23307, 338355
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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