Invitrogen™ FOXP1 Monoclonal Antibody (JC12 (JC-12)), eBioscience™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-139-30	Invitrogen™ 14996282	100 μg

Description

Description: This JC12 monoclonal antibody reacts with human Foxp1, a member of the Forkhead family of winged helix transcription factors. Foxp1 is expressed in nearly every human tissue, including lymphoid (e.g. tonsil, spleen, and thymus), epithelium, kidney, blood, and motor neurons. Altered Foxp1 expression has been observed in, among others, cancers of the breast, lung, colon, prostate, and pancreas. Moreover, patients with diffuse large B cell lymphomas express high levels of Foxp1, which can be utilized as a prognostic marker for survival. Finally, Foxp1 has been reported to be involved in early B cell development (i.e. pro-B cell to pre-B cell transition) and motor neuron specification and connectivity. Applications Reported: This JC12 antibody has been reported for use in immunoblotting (WB), and immunohistology staining of paraffin embedded tissue sections. Applications Tested: This JC12 antibody has been tested by western blot analysis on cell lysates prepared from Jurkat cells. This antibody can be used at 1-5 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: FOXP1
• Concentration: 0.5 mg/mL
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Regulatory Status: RUO
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q9H334
• Gene ID (Entrez): 27086
• Primary or Secondary: Primary
• Purification Method: Affinity Chromatography

• Clone: JC12 (JC-12)
• Content And Storage: 4°C
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG2a κ
• Target Species: Human
• Gene: FOXP1
• Gene Alias: 12CC4; 3110052D19Rik; 4932443N09Rik; AI461938; AW494214; FLJ23741; Fork head related protein like B; fork head-related protein like B; forkhead box P1; forkhead box protein P1; Forkhead box protein P1 (FOXP1); Forkhead-related transcription factor 1; Foxp1; Glutamine rich factor 1; glutamine-rich factor 1; hFKH1B; HSPC215; mac-1-regulated forkhead; MFH; MGC12942; MGC88572; MGC99551; QRF1
• Gene Symbols: FOXP1
• Product Type: Antibody