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Invitrogen™ FRMPD2 Polyclonal Antibody
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Catalog No. PIPA520833
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Quantity:
100 μg
Catalog No. Quantity
PIPA520833 100 μg
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Catalog No. PIPA520833

Supplier: Invitrogen™ PA520833

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat kidney tissue lysate. PA5-20833 can be used with blocking peptide PEP-0947.

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL. FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FRMPD2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene FRMPD2
Gene Accession No. Q68DX3
Gene Alias ENSMUSG00000071536; FERM and PDZ domain containing 2; FERM and PDZ domain-containing protein 2; FRMPD2; Gm1582; Gm626; PDZ domain containing 5C; PDZ domain-containing protein 4; PDZ domain-containing protein 5C; PDZD5C; PDZK4; PDZK5C; predicted gene 626; RGD1565652
Gene Symbols FRMPD2
Host Species Rabbit
Immunogen A 15 amino acid peptide from near the amino terminus of human FRMPD2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 143162, 268729, 498583
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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