Invitrogen™ FRMPD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520833

Catalog No. PIPA520833

Description

A suggested positive control is rat kidney tissue lysate. PA5-20833 can be used with blocking peptide PEP-0947.

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL. FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.

Specifications

• Antigen: FRMPD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FRMPD2
• Gene Alias: ENSMUSG00000071536; FERM and PDZ domain containing 2; FERM and PDZ domain-containing protein 2; FRMPD2; Gm1582; Gm626; PDZ domain containing 5C; PDZ domain-containing protein 4; PDZ domain-containing protein 5C; PDZD5C; PDZK4; PDZK5C; predicted gene 626; RGD1565652
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 143162, 268729, 498583
• Content And Storage: 4°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q68DX3
• Gene Symbols: FRMPD2
• Immunogen: A 15 amino acid peptide from near the amino terminus of human FRMPD2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG