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Fucosyltransferase 3/FUT3 Antibody (SPM194), Alexa Fluor™ 350, Novus Biologicals™
SDP

Catalog No. NP247928A30 Shop All R&D Systems Products
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NP247928A30 0.1 mL
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Catalog No. NP247928A30 Supplier Novus Biologicals Supplier No. NBP247928AF350
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Description

Mouse Monoclonal Antibody

Fucosyltransferase 3/FUT3 Monoclonal specifically detects Fucosyltransferase 3/FUT3 in Human, Guinea Pig samples. It is validated for Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

Antigen Fucosyltransferase 3/FUT3
Applications Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone SPM194
Conjugate Alexa Fluor 350
Dilution Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Symbols FUT3
Host Species Mouse
Immunogen Mucin isolated from a human ovarian cyst fluid (Uniprot: P21217)
Purification Method Protein A or G purified
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 2525.0
Test Specificity The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
Target Species Human, Guinea Pig
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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