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Invitrogen™ FUT8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5113479

Catalog No. PIPA5113479


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Description

Description

FUT8 Polyclonal Antibody for Western Blot, IHC (P), ELISA

Alpha-(1,6)-fucosyltransferase (FUT8) is a gene located on chromosome 14q23.3, encoding an enzyme that catalyzes the addition of fucose to N-glycans via alpha-1,6-linkage. This fucosylation is important in modifying glycoproteins, influencing their function, stability, and interactions within biological systems. FUT8 activity is crucial in various physiological processes, including immune regulation, cell signaling, and development. Aberrant fucosylation patterns, due to altered FUT8 expression, have been associated with pathological conditions such as cancer and inflammatory diseases. In oncology, FUT8-mediated core fucosylation of glycoproteins is linked to tumor progression, metastasis, and therapeutic resistance, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, FUT8's role in immune function highlights its involvement in cellular communication and homeostasis, offering insights into therapeutic strategies aimed at modulating glycosylation pathways to address disease states.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

FUT8
Polyclonal
Unconjugated
FUT8
alpha (1,6) fucosyltransferase; alpha-(1,6)-fucosyltransferase; alpha-1,6-fucosyltransferase; alpha1-6FucT; EC 2.4.1.68; Fucosyltransferase 8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); FUT8; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465
Rabbit
Protein G
RUO
2530, 53618
-20°C or -80°C if preferred
Liquid
ELISA, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Q9BYC5, Q9WTS2
FUT8
Recombinant Human Alpha-(1,6)-fucosyltransferase protein (247-377AA).
100 μg
Primary
Human, Mouse
Antibody
IgG
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