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Invitrogen™ FUT8 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5113479
Description
FUT8 Polyclonal Antibody for Western Blot, IHC (P), ELISA
Alpha-(1,6)-fucosyltransferase (FUT8) is a gene located on chromosome 14q23.3, encoding an enzyme that catalyzes the addition of fucose to N-glycans via alpha-1,6-linkage. This fucosylation is important in modifying glycoproteins, influencing their function, stability, and interactions within biological systems. FUT8 activity is crucial in various physiological processes, including immune regulation, cell signaling, and development. Aberrant fucosylation patterns, due to altered FUT8 expression, have been associated with pathological conditions such as cancer and inflammatory diseases. In oncology, FUT8-mediated core fucosylation of glycoproteins is linked to tumor progression, metastasis, and therapeutic resistance, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, FUT8's role in immune function highlights its involvement in cellular communication and homeostasis, offering insights into therapeutic strategies aimed at modulating glycosylation pathways to address disease states.
Specifications
FUT8 | |
Polyclonal | |
Unconjugated | |
FUT8 | |
alpha (1,6) fucosyltransferase; alpha-(1,6)-fucosyltransferase; alpha-1,6-fucosyltransferase; alpha1-6FucT; EC 2.4.1.68; Fucosyltransferase 8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); FUT8; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465 | |
Rabbit | |
Protein G | |
RUO | |
2530, 53618 | |
-20°C or -80°C if preferred | |
Liquid |
ELISA, Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4 | |
Q9BYC5, Q9WTS2 | |
FUT8 | |
Recombinant Human Alpha-(1,6)-fucosyltransferase protein (247-377AA). | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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