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Invitrogen™ GABRA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA14658

Catalog No. PA14658


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Description

Description

This antibody is predicted to react with bovine, canine, human and non-human primate based on 100% sequence homology. This antibody is specific for the ~51 kDa alpha1-subunit of the GABAA Receptor in Western blots of rat brain.

Gamma -aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date aix alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-R sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Lastly, phosphorylation of beta-subunits of the receptor has been shown to modulate GABAA-R function.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

GABRA1
Polyclonal
Unconjugated
GABRA1
ECA4; EIEE19; EJM; EJM5; GABA alpha subunit; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABAA alpha 1; GABAAR alpha1; GABRA 1; GABRA1; Gabra-1; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1; gamma-aminobutyric acid A receptor alpha 1 variant 1; gamma-aminobutyric acid A receptor alpha 1 variant 2; gamma-aminobutyric acid A receptor alpha 1 variant 3; gamma-aminobutyric acid A receptor alpha 1 variant 4; gamma-aminobutyric acid A receptor, alpha 1; gamma-aminobutyric acid receptor subunit alpha-1; gamma-aminobutyric acid receptor subunit alpha-1-like; gamma-aminobutyric acid type A receptor alpha1 subunit; gamma-aminobutyric acid type A receptor subunit alpha1; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit alpha-1
Rabbit
Affinity chromatography
RUO
14394, 29705
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Immunohistochemistry, Western Blot
∼0.15 mg/mL
0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
P62812, P62813
GABRA1
Fusion protein from the cytoplasmic loop of the alpha 1 subunit of rat GABRA1.
100 μL
Primary
Mouse, Rat
Antibody
IgG
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