Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. NB012970

GAD1/GAD67 Antibody (GAD1/2563), DyLight 680, Novus Biologicals™
SDP

Catalog No. NB012970 Shop All R&D Systems Products
Change view
Click to view available options
Quantity:
0.1 mL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
NB012970 0.1 mL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. NB012970 Supplier Novus Biologicals Supplier No. NBP279937FR
Add to Cart
Add to Cart

Description

Mouse Monoclonal Antibody

GAD1/GAD67 Monoclonal specifically detects GAD1/GAD67 in Human samples. It is validated for Western Blot, Flow Cytometry, ELISA.

Specifications

Antigen GAD1/GAD67
Applications Western Blot, Flow Cytometry, ELISA
Classification Monoclonal
Clone GAD1/2563
Conjugate DyLight 680
Dilution Western Blot, Flow Cytometry, ELISA
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias 67kD), EC 4.1.1, FLJ45882, GAD25, glutamate decarboxylase 1 (brain, 67kDa), Glutamate decarboxylase 67 kDa isoform
Gene Symbols GAD1
Host Species Mouse
Immunogen Recombinant human GAD1/GAD67 protein fragment (around aa 72-135) (exact sequence is proprietary) (Uniprot: Q99259)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Diabetes Research
Primary or Secondary Primary
Test Specificity This monoclonal antibody recognizes a protein of 67kDa, which is identified as glutamic acid decarboxylase 1 (GDA1). There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1. GAD65 and GAD67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD65 localizes to synaptic vesicle membranes in nerve terminals, while GAD67 is distributed throughout the cell. GAD67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD65 will transiently activate to assist in GABA production. The loss of GAD65 is detrimental and can impair GABA neurotransmission, however the loss of GAD67 is lethal.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG2b κ
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.