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Invitrogen™ GATA6 Polyclonal Antibody
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Catalog No. PIPA585601
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100 μL
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PIPA585601 100 μL
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Catalog No. PIPA585601 Supplier Invitrogen™ Supplier No. PA585601
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Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Predicted reactivity: Pig (100%). Positive Control: 293T, 293T nuclear extract. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The GATA6 gene encodes a member of the GATA family of zinc-finger transcription factors, which are critical in regulating gene expression during development. GATA6 plays a crucial role in the differentiation and development of multiple tissues, including the heart and gastrointestinal tract, by interacting with other transcriptional regulators through its zinc-finger domains. This gene influences signaling pathways that drive epithelial-to-mesenchymal transitions (EMTs) and immune surveillance, which are essential processes in maintaining tissue homeostasis and countering tumor progression. In the respiratory tract, GATA6 is essential for the differentiation of lung epithelial cells, impacting the expression of WNT7B and surfactant proteins, vital for proper lung function. Furthermore, studies suggest that GATA6 contributes to an immune-enriched phenotype linked to favorable prognostic outcomes in certain cancers, indicating its potential role in mitigating metastatic propensity by enhancing immune response and surveillance against tumorous cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GATA6
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene GATA6
Gene Accession No. Q92908
Gene Alias AA410133; ASD9; AVSD5; DNA-binding protein GATA-GT2; GATA binding protein 6; Gata6; GATA-6; GATA-binding factor 6; GATA-binding protein 6; LOW QUALITY PROTEIN: transcription factor GATA-6; transcription factor GATA6; transcription factor GATA-6; zinc-finger transcription factor
Gene Symbols GATA6
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human GATA6. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2627
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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