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Thermo Scientific™ GeneBLAzer™ MC4R-CRE-bla CHO-K1 Cells

Catalog No. K1738
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K1738 2 x 106 Cells
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Catalog No. K1738 Supplier Thermo Scientific™ Supplier No. K1738

Please call customer service for current pricing. 1-800-766-7000

Description

GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 4 (MC4R) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line.

GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 4 (MC4R) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™ CRE-bla CHO-K1 cells (Cat. No. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.

The GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of α MSH In addition, GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

MC4 receptors are expressed almost exclusively in the CNS and bind all of the melanocortin peptides, but only have high affinity for α-MSH and ACTH. The agouti peptide binds to the MC4R receptor with high affinity in in vitro tests but, being normally expressed only in skin, doesn't have access to the MC4R receptor under physiological conditions. The AGRP peptide is a high-affinity antagonist of the neural MC4R receptor. The MC4R receptor is involved in the regulation of energy homeostasis and erectile function.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.

TRUSTED_SUSTAINABILITY

Specifications

Accession Number NM_005912
Assay Entry Cell-based beta lactamase reporter gene
Cell State Dividing Cells
Content And Storage LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.

Includes:
• GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells
• GeneBLAzer™ MC4R-CRE-bla CHO-K1 Assay Protocol
• Certificate of Analysis

The GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
Detection Method Fluorescence
For Use With (Application) FRET
Gene Symbol MC4R
Population Status Single Cell Clone Origin
Product Line GeneBLAzer
Quantity 2 x 106 Cells
Reporter Gene BLA (Beta-Lactamase)
Target Entry MC4R
Cell Line CHO-K1
System Type GeneBLAzer™
Druggable Target GPCR
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For Research Use Only. Not for use in diagnostic procedures.

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