GFI1 Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-3491	Active Motif 61554	10 μL
50-199-3490	Active Motif 61553	100 μL

Description

GFI1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.

Specifications

• Antigen: GFI1
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q99684
• Gene ID (Entrez): 2672
• Immunogen: This antibody was raised against a peptide within the N-terminal region of human GFI1.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: GFI1

• Concentration: Lot-Specific
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Alias: AW495828; FLJ94509; GFI1; Gfi-1; GFI1A; growth factor independence-1; growth factor independent 1; growth factor independent 1 transcription repressor; growth factor independent 1 transcriptional repressor; Growth factor independent protein 1; Growth factor independent-1; Pal1; Pal-1; SCN2; Zinc finger protein 163; Zinc finger protein Gfi-1; ZNF163
• Gene Symbols: GFI1
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody