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GGCX Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 162091AP

Catalog No. 50-173-0792

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GGCX (gamma-glutamyl carboxylase), also known as GC or VKCFD1 (Vitamin K-dependent gamma-carboxylase), is a 758 amino acid multi-pass membrane protein. Localized to the membrane of the endoplasmic reticulum, GGCX functions to mediate the vitamin K-dependent carboxylation of glutamate residues on target proteins, thereby producing calcium binding gamma-carboxyglutamate (Gla) residues on these proteins and simultaneously converting vitamin K to vitamin K epoxide. GGCX exists as a monomer and, via its ability to modify glutamate residues, it accomplishes the post-translational changes that are necessary for the activity of all vitamin K-dependent proteins (such as blood coagulation and bone matrix proteins). Defects in the gene encoding GGCX are the cause of combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) and PXE-like disorder with multiple coagulation factor deficiency, both of which are characterized by abnormal skin, blood or bone function.


0.22 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O88496, P38435, Q9QYC7
gamma glutamyl carboxylase, GC, GGCX, VKCFD1
150 μL
2677, 56316, 81716
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
GGCX Fusion Protein Ag9185
Antigen Affinity Chromatography
Human, Mouse, Rat
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