Invitrogen™ GILZ Monoclonal Antibody (CFMKG15), eBioscience™, Invitrogen™

Catalog No.	Quantity
14-403-337	2 mg

Catalog No. 14-403-337 Supplier Invitrogen™ Supplier No. 14403337

Description

Rat Monoclonal Antibody

GILZ is a leucine-zipper-containing protein that is induced by glucocorticoids. It is expressed in mast cells, monocytes, macrophages, dendritic cells, and T cells. GILZ has been shown to inhibit production of IL-2 as well as TCR-driven upregulation of FasL. GILZ mediates these changes in transcription, at least in part, by inhibiting DNA-binding of the transcription factors AP-1 and NF-kappaB. GILZ has also been shown to mediate anti-inflammatory signals in macrophages and dendritic cells by interfering with NF-kappaB-mediated signaling. Although GILZ has been reported to localize to the nucleus, more recent reports as well as testing at eBioscience have observed predominantly cytoplasmic staining.

The TSC22 domain family member 3 protein (TSC22D3) is a leucine zipper protein that functions as a transcriptional regulator. The expression of TSC22D3 is stimulated by glucocorticoids and IL-10 and is thought to play a key role in the anti-inflammatory and immunosuppressive effects of these molecules. TSC22D3 can physically interact with and inhibit the activities of key inflammatory signaling mediators such NF-Kappa-B and AP-1. TSC22D3 functions as a transcriptional co-activator for various nuclear receptors and NF-Kappa-B. It has also been shown to be involved in the differentiation of mesenchymal stem cells towards osteoblasts and bone formation.

Specifications

• Antigen: GILZ
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: CFMKG15
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene: TSC22D3
• Gene Accession No.: Q99576, Q9Z2S7
• Gene Alias: delta sleep inducing peptide, immunoreactor; delta sleep-inducing peptide immunoreactor; DIP; Dsip1; DSIPI; DSIP-immunoreactive leucine zipper protein; DSIP-immunoreactive peptide; GILZ; glucocorticoid-induced leucine zipper protein; long glucocorticoid-induced leucine zipper protein; Protein DIP; Tilz3; TSC22 domain family 3; TSC22 domain family member 3; TSC22 domain family protein 3; TSC22 domain family, member 3; TSC-22 related protein; TSC22D3; TSC-22-like protein; TSC-22R; TSC22-related inducible leucine zipper 3; TSC-22-related protein; TSC22-related-inducible leucine zipper 3
• Gene Symbols: TSC22D3
• Host Species: Rat
• Purification Method: Affinity chromatography
• Quantity: 2 mg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 14605, 1831
• Target Species: Human, Mouse
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a κ