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  5. Tocris Bioscience™ Givinostat hydrochloride

Tocris Bioscience™ Givinostat hydrochloride
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Catalog No. p-7116116
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Quantity:
5 mg
25 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Histone deacetylase inhibitor

Givinostat hydrochloride is a histone deacetylase (HDAC) inhibitor (IC50 = 7.5 to 16 nM). At low concentrations reduces release of pro-inflammatory cytokines, including TNFα, INFγ, IL-1α and IL-1β, from LPS stimulated PBMCs in vitro. Exhibits anti-inflammatory effects in vivo. Improves functional recovery and attenuates tissue damage in a mouse model of traumatic brain injury.

Specifications

Chemical Name or Material [6-[(Diethylamino)methyl]-2-naphthalenyl]methyl-N-[4-[(hydroxyamino)carbonyl]phenyl]carbamate hydrochloride
CAS 199657-29-9
Assay Percent Range >98%
Quantity 25 mg
Molecular Formula C24H27N3O4.HCl
Formula Weight Observed MW: 457.95
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