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Glypican 3 Antibody (1G12 + GPC3/863) - IHC-Prediluted, Novus Biologicals™
SDP

Catalog No. NBP248418 Shop All R&D Systems Products
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NBP248418 7 mL
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Catalog No. NBP248418 Supplier Novus Biologicals Supplier No. NBP248418
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Description

Mouse Monoclonal Antibody

Glypican 3 Monoclonal specifically detects Glypican 3 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Glypican 3
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 1G12 + GPC3/863
Conjugate Unconjugated
Dilution Immunohistochemistry-Paraffin
Formulation 1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias DGSX, glypican 3, glypican proteoglycan 3, glypican-3, GTR2-2, heparan sulphate proteoglycan, Intestinal protein OCI-5, MXR7, OCI5, OCI-5, secreted glypican-3, SGB, SGBS, SGBS1SDYS
Gene Symbols GPC3
Host Species Mouse
Immunogen Recombinant fragment containing amino acids 511-580 of human Glypican 3 (1G12); Recombinant full-length human GPC3 protein (GPC3/863) (Uniprot: P51654)
Molecular Weight of Antigen 67 kDa
Purification Method Protein A or G purified
Quantity 7 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2719
Test Specificity Glypican-3 (GPC3) is an integral membrane protein that is mutated in the Simpson-Golabi-Behmel syndrome (SGBS). SGBS is characterized by pre- and post-natal overgrowth and is a recessive X-linked condition.GPC3 may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma was significantly higher than that of follicular adenoma. In contrast, GPC 3 is not expressed in anaplastic carcinoma.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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