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  8. GNF 5837, Tocris Bioscience™ 

GNF 5837, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
10mg
50mg
This item is not returnable. View return policy
1033769-28-6
C28H21F4N5O2
535.503
YYDUWLSETXNJJT-MTJSOVHGSA-N
z-1-3-3-1h-pyrrol-2-yl methylene-2-oxoindolin-6-yl amino-4-methylphenyl-3-2-fluoro-5-trifluoromethyl phenyl urea,1-2-fluoro-5-trifluoromethyl phenyl-3-4-methyl-3-3z-2-oxo-3-1h-pyrrol-2-ylmethylidene-1h-indol-6-yl amino phenyl urea,d02rwc,n-3-2,3-dihydro-2-oxo-3-1h-pyrrol-2-ylmethylene-1h-indol-6-yl amino-4-methylphenyl-n'-2-fluoro-5-trifluoromethyl phenyl urea,2-2-2-methoxy-4-4-morpholinyl phenyl amino-5-trifluoromethyl-4-pyridinyl amino-n-methylbenzamide,3-2-fluoro-5-trifluoromethyl phenyl-1-4-methyl-3-3z-2-oxo-3-1h-pyrrol-2-ylmethylidene-1h-indol-6-yl amino phenyl urea,n-3-2,3-dihydro-2-oxo-3-1h-pyrrol-2-ylmethylene-1h-indol-6-yl amino-4-methylphenyl-n'-2-fluoro-5-trifluoromethyl phenyl-urea
59397065
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]urea
CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)C(=CC5=CC=CN5)C(=O)N4
This item is not returnable. View return policy
1033769-28-6
C28H21F4N5O2
535.503
YYDUWLSETXNJJT-MTJSOVHGSA-N
z-1-3-3-1h-pyrrol-2-yl methylene-2-oxoindolin-6-yl amino-4-methylphenyl-3-2-fluoro-5-trifluoromethyl phenyl urea,1-2-fluoro-5-trifluoromethyl phenyl-3-4-methyl-3-3z-2-oxo-3-1h-pyrrol-2-ylmethylidene-1h-indol-6-yl amino phenyl urea,d02rwc,n-3-2,3-dihydro-2-oxo-3-1h-pyrrol-2-ylmethylene-1h-indol-6-yl amino-4-methylphenyl-n'-2-fluoro-5-trifluoromethyl phenyl urea,2-2-2-methoxy-4-4-morpholinyl phenyl amino-5-trifluoromethyl-4-pyridinyl amino-n-methylbenzamide,3-2-fluoro-5-trifluoromethyl phenyl-1-4-methyl-3-3z-2-oxo-3-1h-pyrrol-2-ylmethylidene-1h-indol-6-yl amino phenyl urea,n-3-2,3-dihydro-2-oxo-3-1h-pyrrol-2-ylmethylene-1h-indol-6-yl amino-4-methylphenyl-n'-2-fluoro-5-trifluoromethyl phenyl-urea
59397065
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]urea
CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)C(=CC5=CC=CN5)C(=O)N4

Description

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 μM respectively). Orally bioavailable.

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Quantity 10mg
Formula Weight 535.49
Percent Purity >98%
Chemical Name or Material GNF 5837

Safety and Handling

Recommended Storage : Store at +4°C