GNF 5837, Tocris Bioscience™

Description

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 μM respectively). Orally bioavailable.

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Specifications

Chemical Identifiers

• CAS: 1033769-28-6
• Molecular Formula: C28H21F4N5O2
• Molecular Weight (g/mol): 535.50
• MDL Number: MFCD24386809
• InChI Key: YYDUWLSETXNJJT-UHFFFAOYSA-N
• Synonym: z-1-3-3-1h-pyrrol-2-yl methylene-2-oxoindolin-6-yl amino-4-methylphenyl-3-2-fluoro-5-trifluoromethyl phenyl urea, 1-2-fluoro-5-trifluoromethyl phenyl-3-4-methyl-3-3z-2-oxo-3-1h-pyrrol-2-ylmethylidene-1h-indol-6-yl amino phenyl urea, d02rwc, n-3-2,3-dihydro-2-oxo-3-1h-pyrrol-2-ylmethylene-1h-indol-6-yl amino-4-methylphenyl-n'-2-fluoro-5-trifluoromethyl phenyl urea, 2-2-2-methoxy-4-4-morpholinyl phenyl amino-5-trifluoromethyl-4-pyridinyl amino-n-methylbenzamide, 3-2-fluoro-5-trifluoromethyl phenyl-1-4-methyl-3-3z-2-oxo-3-1h-pyrrol-2-ylmethylidene-1h-indol-6-yl amino phenyl urea, n-3-2,3-dihydro-2-oxo-3-1h-pyrrol-2-ylmethylene-1h-indol-6-yl amino-4-methylphenyl-n'-2-fluoro-5-trifluoromethyl phenyl-urea
• PubChem CID: 59397065
• IUPAC Name: 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-({2-oxo-3-[(1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-6-yl}amino)phenyl]urea
• SMILES: CC1=C(NC2=CC3=C(C=C2)C(=CC2=CC=CN2)C(=O)N3)C=C(NC(=O)NC2=C(F)C=CC(=C2)C(F)(F)F)C=C1

• Quantity: 50 mg
• Formula Weight: 535.49
• Percent Purity: >98%
• Chemical Name or Material: GNF 5837

Safety and Handling

Recommended Storage

Store at +4°C