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GSK 2193874, Tocris Bioscience™

Potent and selective TRPV4 antagonist; orally active

Manufacturer:  Tocris Bioscience 5106/5

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Catalog No. 51-065


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Description

Description

Potent and selective TRPV4 antagonist (IC50 values are 2 and 40 nM for rat and human receptors, respectively); inhibits Ca2+ influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarction in vivo models. Selective over a panel of ~200 human receptors, channels and enzymes. Orally active.
Specifications

Specifications

3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
>98%
Observed MW: 691.62
1336960-13-4
C37H38BrF3N4O
5mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at 4°C

SDS
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