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Tocris Bioscience™ GSK 2334470
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Catalog No. 414350
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Catalog No. Quantity
41-435-0 50 mg
41-431-0 10 mg
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Catalog No. 41-435-0 Supplier Tocris Bioscience™ Supplier No. 4143/50
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Description

Highly potent, selective PDPK1 (PDK1) inhibitor

Potent 3-phosphoinositide-dependent protein kinase (PDPK1) inhibitor (IC50 ∽ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice.

Chemical Identifiers

CAS 1227911-45-6
Molecular Formula C25H34N8O

Specifications

Quantity 50 mg
Formula Weight 462.59
Purity >98%
Molecular Weight (g/mol) 462.602
Chemical Name or Material GSK 2334470

Safety and Handling

Recommended Storage Store at +4°C
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