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  5. Tocris Bioscience™ GSK 2606414

Tocris Bioscience™ GSK 2606414
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Catalog No. p-5545811
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective PERK inhibitor; orally bioavailable

GSK 2606414 is a potent and selective protein kinase R-like ER kinase (PERK) inhibitor (IC50 = 0.4 nM). Exhibits >1000-fold selectivity for PERK over HR1 and PKR. Inhibits thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells. Attenuates subcutaneous pancreatic human tumor xenograft growth in mice. Orally bioavailable.

Specifications

Quantity 10 mg
Product Type GSK 2606414
Purity >99%
Molecular Weight (g/mol) 451.44
Inhibitors GSK 2606414

For Research Use Only

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