Tocris GSK 2606414
Potent and selective PERK inhibitor; orally bioavailable
Manufacturer: Tocris 5107/10
DescriptionPotent and selective protein kinase R-like ER kinase (PERK) inhibitor (IC50 = 0.4nM). Exhibits >1000-fold selectivity for PERK over HR1 and PKR. Inhibits thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells. Attenuates subcutaneous pancreatic human tumor xenograft growth in mice. Orally bioavailable.
- Chemical Name: 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone
- Formula: C24H20F3N5O
- CAS Number: 1337531-36-8
- Solubility: Soluble to 100mM in DMSO and to 20mM in 1eq. HCl with gentle warming
- Purity: >99
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