Tocris GSK 650394
Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
Manufacturer: Tocris 3572/50
DescriptionSerum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 values are 62 and 103nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1µM).
- Chemical Name: 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid
- Formula: C25H22N2O2
- CAS Number: 890842-28-1
- Solubility: Soluble to 100mM in DMSO
- Purity: >97
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