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Tocris Bioscience™ GSK J1
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Catalog No. 459350
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Catalog No. Quantity
45-935-0 50 mg
45-931-0 10 mg
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Catalog No. 45-935-0 Supplier Tocris Bioscience™ Supplier No. 4593/50
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Description

Potent JMJD3/UTX inhibitor

Potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC50 values are 28 and 53 nM respectively). Also inhibits KDM5B, KDM5C and KDM5A (IC50 values are 170, 550 and 6,800 nM respectively). Exhibits no activity against a panel of other histone demethylases (IC50 >20 μM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 μM.

Ethyl ester derivative and Negative Control also available.

Chemical Identifiers

CAS 1373422-53-7
Molecular Formula C22H23N5O2

Specifications

Quantity 50 mg
Formula Weight 389.45
Purity >99%
Molecular Weight (g/mol) 389.459
Chemical Name or Material GSK J1

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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