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GSK J1, Tocris Bioscience™

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Quantity:
10mg
50mg
This item is not returnable. View return policy
1373422-53-7
C22H23N5O2
389.459
AVZCPICCWKMZDT-UHFFFAOYSA-N
gsk-j1,gsk j1,gskj1,3-2-pyridin-2-yl-6-2,3,4,5-tetrahydro-1h-3-benzazepin-3-yl pyrimidin-4-yl amino propanoic acid,3-6-4,5-dihydro-1h-benzo d azepin-3 2h-yl-2-pyridin-2-yl pyrimidin-4-yl amino propanoic acid,3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3-benzazepin-3-yl pyrimidin-4-yl amino propanoic acid,k0i,d0s3dd,gskj1; gsk-j1,gsk-j hplc
56963315
3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid
C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O
This item is not returnable. View return policy
1373422-53-7
C22H23N5O2
389.459
AVZCPICCWKMZDT-UHFFFAOYSA-N
gsk-j1,gsk j1,gskj1,3-2-pyridin-2-yl-6-2,3,4,5-tetrahydro-1h-3-benzazepin-3-yl pyrimidin-4-yl amino propanoic acid,3-6-4,5-dihydro-1h-benzo d azepin-3 2h-yl-2-pyridin-2-yl pyrimidin-4-yl amino propanoic acid,3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3-benzazepin-3-yl pyrimidin-4-yl amino propanoic acid,k0i,d0s3dd,gskj1; gsk-j1,gsk-j hplc
56963315
3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid
C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O

Potent JMJD3/UTX inhibitor

Potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC50 values are 28 and 53 nM respectively). Also inhibits KDM5B, KDM5C and KDM5A (IC50 values are 170, 550 and 6,800 nM respectively). Exhibits no activity against a panel of other histone demethylases (IC50 >20 μM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 μM.

Ethyl ester derivative and Negative Control also available.

Formula Weight 389.45
Percent Purity >99%
Quantity 50mg
Chemical Name or Material GSK J1

Recommended Storage : Desiccate at Room Temperature