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  5. GSK J1, Tocris Bioscience™

GSK J1, Tocris Bioscience™

Catalog No. 459350
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent JMJD3/UTX inhibitor

Potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC50 values are 28 and 53 nM respectively). Also inhibits KDM5B, KDM5C and KDM5A (IC50 values are 170, 550 and 6,800 nM respectively). Exhibits no activity against a panel of other histone demethylases (IC50 >20 μM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 μM.

Ethyl ester derivative and Negative Control also available.

Chemical Identifiers

CAS 1373422-53-7
Molecular Formula C22H23N5O2
Molecular Weight (g/mol) 389.459
InChI Key AVZCPICCWKMZDT-UHFFFAOYSA-N
Synonym gsk-j1, gsk j1, gskj1, 3-2-pyridin-2-yl-6-2,3,4,5-tetrahydro-1h-3-benzazepin-3-yl pyrimidin-4-yl amino propanoic acid, 3-6-4,5-dihydro-1h-benzo d azepin-3 2h-yl-2-pyridin-2-yl pyrimidin-4-yl amino propanoic acid, 3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3-benzazepin-3-yl pyrimidin-4-yl amino propanoic acid, k0i, d0s3dd, gskj1; gsk-j1, gsk-j hplc
PubChem CID 56963315
IUPAC Name 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid
SMILES C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O

Specifications

Formula Weight 389.45
Percent Purity >99%
Quantity 50 mg
Chemical Name or Material GSK J1

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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