Invitrogen™ GSTA3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121942

Catalog No. PIPA5121942

Description

GSTA3 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.

Specifications

• Antigen: GSTA3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gsta3
• Gene Alias: glutathione S-alkyltransferase A3; glutathione S-aralkyltransferase A3; glutathione S-aryltransferase A3; glutathione S-transferase A3; glutathione S-transferase A3 subunit; glutathione S-transferase A3-3; glutathione S-transferase A5; glutathione S-transferase alpha 1; glutathione S-transferase alpha 3; glutathione S-transferase alpha-3; Glutathione S-transferase alpha-5; glutathione S-transferase Ya3; Glutathione S-transferase Yc; glutathione S-transferase Yc-1; glutathione S-transferase Yc1 subunit; Glutathione S-transferase Yc-2; glutathione S-transferase Yc2 subunit; glutathione S-transferase, alpha 3; Glutathione-S-transferase alpha type (Ya); GST 2-2; GST A3-3; GST A5-5; GST AA; GST class-alpha member 3; GST Yc1; GST Yc2; Gst2-3; Gsta1; GSTA3; GSTA3-3; Gsta5; Gstyc; Gstyc1; Gstyc2; GTA3; MGC22232; S-(hydroxyalkyl)glutathione lyase A3; Yc1; Yc2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14859
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 500 μg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300
• Gene Accession No.: P30115
• Gene Symbols: Gsta3
• Immunogen: Recombinant protein Glutathione S Transferase Alpha 3. The antigen corresponds to amino acid range 1-221 of the target protein.
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG