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HBP1 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA538537
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100 μg
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PIPA538537 100 μg
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Catalog No. PIPA538537 Supplier Thermo Scientific Supplier No. PA538537

Description

Rabbit Polyclonal Antibody

The HMG-box protein-1 (HBP1) is a member of the HMG family of transcription factors, which are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, that mediates DNA binding. HBP1 binds to the tumor suppressor proteins Rb and p130 and initiates cell cycle arrest. Terminal cell differentiation requires this initial cell cycle arrest followed by the coordinated expression of genes defined as tissue-specifc markers. Along with initiating the commitment to cell differentiation, the continued activity of HBP1 abrogates the expression of tissue-specific genes by associating with the MyoD proteins. In muscle cell differentiation, the MyoD family of transcription factors, which include Myf5, MyoD and myogenein, induce the expression of these cell-type specific proteins and contribute to the development of cell phenotypes. The progression of terminal differentiation is, therefore, dependent on both a decrease in HBP1 activity and the corresponding activation of MyoD-induced gene transcription.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HBP1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene HBP1
Gene Accession No. O60381, Q8R316, Q62661
Gene Alias HMG box-containing protein 1, HMG box transcription factor 1, High mobility group box transcription factor 1, HBP1
Gene Symbols HBP1
Host Species Rabbit
Immunogen A synthetic peptide derived from the internal region of human HBP1
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26959, 27080, 73389
Target Species Human, Mouse, Non-human Primate, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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