Invitrogen™ Hepsin Polyclonal Antibody

Catalog No.	Quantity
PIPA582265	100 μL

Catalog No. PIPA582265

Supplier: Invitrogen™ PA582265

Description

Rabbit Polyclonal Antibody

Immunogen sequence: FDKTEGTWRL LCSSRSNARV AGLSCEEMGF LRALTHSELD VRTAGANGTS GFFCVDEGRL PHTQRLLEVI SVCDCPRGRF LAAICQDCGR RKLPVDRIVG GRDTSLGRWP WQVSLRYDGA HL Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 90%.

Hepsin, encoded by the HPN gene, is a type II transmembrane serine protease prominently expressed in tissues such as the liver, kidney, and prostate. Hepsin plays a crucial role in proteolytic processes involved in extracellular matrix remodeling, cell growth, and development. It is known for activating precursor molecules, including hepatocyte growth factor (HGF), which is essential for liver development and regeneration. Furthermore, hepsin's involvement extends to influencing cell signaling pathways related to tissue homeostasis and repair. In the context of cancer, particularly prostate cancer, hepsin is implicated in tumor progression and metastasis by promoting extracellular matrix degradation, thereby facilitating tumor invasion and spread. Aberrant expression or activity of hepsin is associated with pathophysiological changes in the tumor microenvironment, making it a target for therapeutic interventions aimed at controlling cancer progression. Research continues to explore hepsin's biochemical functions and regulatory mechanisms, providing insights into its potential roles in both normal physiology and disease states.

Specifications

• Antigen: Hepsin
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: HPN
• Gene Accession No.: P05981
• Gene Alias: hepsin; hepsin (transmembrane protease, serine 1); Hlb320; HPN; Serine protease hepsin; Serine protease hepsin catalytic chain; Serine protease hepsin non-catalytic chain; testicular tissue protein Li 85; TMPRSS1; Transmembrane protease serine 1
• Gene Symbols: HPN
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human HPN. Recombinant protein control fragment (Product #RP-89245).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3249
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG