HFE2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-7433	Proteintech Group Inc 117581AP150UL	150 μL

Description

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Specifications

• Antigen: HFE2
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q6ZVN8, Q7TQ32, Q8N7M5
• Gene ID (Entrez): 148738, 310681, 69585
• Immunogen: HFE2 Fusion Protein Ag2354
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: HFE2

• Concentration: 0.2 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: Hemochromatosis type 2 protein, Hemojuvelin, HFE2, HFE2A, HJV, JH, RGM domain family member C, RGMC
• Gene Symbols: Hfe2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody