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  6. HIRA Monoclonal Antibody (WC119.2H11), Active Motif™ 

HIRA Monoclonal Antibody (WC119.2H11), Active Motif™
SDP

Catalog No. p-7188907
Encompass
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50-199-2720 10 μg
50-199-2719 100 μg
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Catalog No. 50-199-2720 Supplier Active Motif Supplier No. 39558
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Description

Mouse Monoclonal Antibody

HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Specifications

Antigen HIRA
Applications Western Blot
Classification Monoclonal
Clone WC119.2H11
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene HIRA
Gene Accession No. P54198, Q61666
Gene Alias AA138857; D16Ertd95e; DGCR1; DiGeorge critical region gene 1; Gm15797; HIR; HIR histone cell cycle regulation defective homolog A; Hira; histone cell cycle regulation defective homolog A; histone cell cycle regulation defective homolog A (S. cerevisiae); histone cell cycle regulator; N28177; OTTMUSG00000026264; Protein HIRA; TUP1; TUP1-like enhancer of split gene 1; TUP1-like enhancer of split protein 1; Tuple1
Gene Symbols HIRA
Host Species Mouse
Immunogen This HIRA antibody was raised against a GST-fusion protein containing residues 421-729 of human HIRA.
Purification Method Protein G
Quantity 10 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15260, 7290
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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