Invitrogen™ HLA-DR beta Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521410

Catalog No. PIPA521410

Description

Recommended positive controls: Raji. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

HLA-DR beta refers to the beta chain of the HLA-DR protein complex, which is a member of the human leukocyte antigen (HLA) class II molecule. The HLA-DR beta chain is encoded by the HLA-DRB gene. HLA-DR beta is primarily on the surface of antigen-presenting cells, including dendritic cells, macrophages, and B cells. These cells play a crucial role in the immune system by capturing, processing, and presenting antigens to T cells for immune recognition. HLA-DR beta is a critical component of the immune system, facilitating the recognition and response to extracellular antigens. Its function in presenting antigenic peptides to CD4+ T cells plays a vital role in the activation of adaptive immune responses. HLA-DR beta consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain contains the peptide-binding groove, which interacts with antigenic peptides. The transmembrane domain anchors the HLA-DR beta chain to the cell membrane, while the cytoplasmic tail is involved in intracellular signaling events. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Specifications

• Antigen: HLA-DR beta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HLA-DRB5
• Gene Alias: Clone P2-beta-3; DAMC-146E17.2; DR beta-5; DR-16; DR2-beta-2; DR4; DR-4; DR7; DR9; DR-9; DRB1; DRB1 transplantation antigen; DRB4; DRw10; dw2; DW2.2/DR2.2; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1-15 beta chain; HLA class II histocompatibility antigen, DRB1-16 beta chain; HLA class II histocompatibility antigen, DRB1-3 chain; HLA class II histocompatibility antigen, DRB1-7 beta chain; HLA class II histocompatibility antigen, DRB1-9 beta chain; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRB; HLA-DRB1; HLA-DRB2; HLA-DRB3; HLA-DRB4; HLA-DRB5; human leucocyte antigen DRB1; human leucocyte antigen DRB3; human leucocyte antigen DRB4; human leucocyte antigen DRB5; leukocyte antigen; leukocyte antigen class II; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1; major histocompatibility complex, class II, DR beta 3; major histocompatibility complex, class II, DR beta 4; major histocompatibility complex, class II, DR beta 5; MHC class I antigen; MHC class II antigen; MHC class II antigen DR beta 3 chain; MHC class II antigen DRB1*15; MHC class II antigen DRB1*16; MHC class II antigen DRB1*3; MHC class II antigen DRB1*9; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II antigen HLA-DR-beta; MHC class II HLA beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class2 antigen; MHC HLA DR-beta chain; MHC HLA-DR-beta cell surface glycoprotein; MHC HLA-DR-beta chain; SS1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3123, 3125, 3126, 3127
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P01911, P13762, P79483, Q30154
• Gene Symbols: HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 266 of HLA DR beta (Uniprot ID#P13762).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG