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HLA-DRB5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
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Catalog No. p-7209920 Shop All Proteintech Group Inc Products
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50-173-3554 150 μL
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Catalog No. 50-173-3554 Supplier Proteintech Group Inc Supplier No. 217021AP150UL
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Description

Rabbit Polyclonal Antibody

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Specifications

Antigen HLA-DRB5
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.17 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene HLA-DRB5
Gene Accession No. Q30154
Gene Alias DR beta 2, DR beta 5, Dw2, HLA DRB, HLA DRB5, HLA-DRB5, MHC class II antigen DRB5
Gene Symbols HLA-DRB5
Host Species Rabbit
Immunogen HLA-DRB5 Fusion Protein Ag16307
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3127
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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